What peptide isolated by Sérgio Henrique Ferreira led to the development of ACE inhibitors for hypertension?
Answer
Bradykinin-potentiating peptide (BPP)
Sérgio Henrique Ferreira, a Brazilian scientist, achieved a major medical breakthrough in 1965 by isolating the bradykinin-potentiating peptide (BPP) directly from the venom of *B. jararaca*. This peptide exhibited a significant capability to reduce blood pressure in test subjects. This foundational discovery provided the specific biochemical target that directly inspired and paved the way for the subsequent creation and global implementation of Angiotensin Converting Enzyme (ACE) inhibitors, a class of drugs exemplified by captopril, which fundamentally changed the treatment landscape for hypertension and certain forms of congestive heart failure.
Related Questions
What peptide isolated by Sérgio Henrique Ferreira led to the development of ACE inhibitors for hypertension?Which behavior utilizes the white tail tip by juvenile *B. jararaca* to attract prey?What is the primary prey difference reflecting the ontogenetic diet shift in *B. jararaca*?What is the most abundant major component quantified in the venom composition of *B. jararaca*?What specific pattern often seen along the spine distinguishes *Bothrops alternatus* from *B. jararaca*?In the reproductive cycle of *B. jararaca*, when does parturition (live birth) typically occur?Which gender of *B. jararaca* exhibits greater potency regarding hemorrhagic and hyaluronidasic venom activities?What distinctive physical characteristic is typically found on the tail tip of juvenile *B. jararaca* specimens?What classification does the IUCN Red List currently assign to *Bothrops jararaca*?Which enzyme found in *B. jararaca* venom has been clinically applied as an antihemorrhagic drug?Where is *Bothrops jararaca* endemic, spanning southern Brazil into which two other countries?Which activity associated with venom potency is greater in male *B. jararaca* venom compared to female venom?