Which specific gene is identified as responsible for regulating pheomelanin production in white tigers?

Answer

The SLC45A2 gene.

The specific genetic mechanism responsible for the white coloration has been identified as residing within the SLC45A2 gene. This gene carries a critical function in the biological pathways responsible for producing various pigments in the fur. Specifically, the dominant version of the allele found in standard orange tigers permits the full production and expression of pheomelanin, which is the pigment responsible for generating red and yellow hues. The recessive mutation in SLC45A2 effectively disrupts or blocks the necessary steps for the full development of this pheomelanin, resulting in the characteristic white background.

Which specific gene is identified as responsible for regulating pheomelanin production in white tigers?
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