What dental issue correlates directly with the FOXI3 mutation in Xoloitzcuintli?
Answer
Missing premolars
The mutation in the *FOXI3* gene responsible for the hairless phenotype has a secondary, yet recognized, effect on skeletal development, specifically impacting the teeth. This correlation dictates that the presence of the hairless gene leads to abnormal development of the tooth structure. The direct manifestation of this anomaly in the Xoloitzcuintli breed standard is the absence of certain teeth, most notably the missing premolars. This connection is a vital piece of practical knowledge for owners, linking scientific genetics to required proactive veterinary dental care.
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