What genetic issue causes the Zorse to be almost universally sterile?

Answer

Uneven total chromosome count prevents matching pairs during meiosis

The fundamental barrier preventing fertility in the zorse is the substantial difference in chromosome counts between the horse parent (64 chromosomes) and the zebra parent (variable, e.g., 32 to 46). When the sex cells (sperm and egg) combine, the resulting zorse inherits an uneven total number of chromosomes, typically falling between 50 and 63. This uneven count means that homologous chromosomes cannot form the necessary matching pairs required for successful pairing during meiosis, the cell division process crucial for generating viable sex cells (sperm or eggs). Therefore, the inherent genetic incompatibility locks the zorse into being a sterile crossbreed.

What genetic issue causes the Zorse to be almost universally sterile?

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