What crucial function does the protein produced by the MDR1 gene perform in Collies?
Answer
Pumping certain drugs out of the brain
The MDR1 (Multi-Drug Resistance) Mutation represents a defect in a gene that codes for a specific protein designed to actively transport certain pharmacological agents, primarily drugs, out of the central nervous system, or the brain. When this protein function is impaired due to the mutation, common medications, including some antibiotics and anti-parasitics such as ivermectin, can reach toxic concentrations within the brain tissue. This accumulation leads to severe, potentially lethal, neurological toxicity in affected dogs, emphasizing why knowing a dog's MDR1 status is vital for safe prescribing practices.
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