Are wolf spider bites generally considered medically significant to humans?

No, symptoms are usually minor, akin to a bee sting.

Wolf spiders are generally not considered medically significant to the human population. While they possess venom and the necessary fangs to bite, this action is almost always defensive, occurring only if the spider feels trapped or threatened, such as being accidentally pressed against skin. The venom delivered in such defensive encounters is typically not potent enough to cause serious systemic harm to healthy individuals. The resulting symptoms are usually localized and transient, most commonly described as being similar to a mild bee sting, involving localized pain, slight redness, or minor swelling at the site of the bite, without leading to the severe outcomes associated with some other spider groups.