What is the primary reason most first-generation zonkeys are sterile?

Answer

The significant difference in chromosome count between the parents

The sterility found in most zonkeys is a direct biological consequence of the genetic incompatibility between the parents. Zebras carry around 46 chromosomes, while donkeys carry 62. This mismatch creates a situation where the resulting hybrid offspring cannot produce viable reproductive cells because the chromosomes cannot pair successfully during meiosis. This biological barrier exists even though both species belong to the same genus, *Equus*, and fundamentally distinguishes hybridizing these species from crossing breeds within the same species, such as different types of horses.

What is the primary reason most first-generation zonkeys are sterile?
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