What major factor, if neglected, will inevitably lead to a defensive, unfriendly animal regardless of species?

Answer

Stress from incorrect temperature, humidity, or enclosure size

Stress resulting from incorrect husbandry elements like temperature, humidity, or inadequate enclosure size will predictably result in a defensive and unfriendly animal.

What major factor, if neglected, will inevitably lead to a defensive, unfriendly animal regardless of species?

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